BMP agonist 1
BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP) . BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1].
Product Specifications
UNSPSC
12352005
Target
GSK-3; TGF-β Receptor; β-catenin
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/bmp-agonist-1.html
Solubility
10 mM in DMSO
Smiles
OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O
Molecular Formula
C21H16N2O6
Molecular Weight
392.36
References & Citations
[1]Riege D, et al. Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers. ACS Pharmacol Transl Sci. 2023 Jul 19;6 (8) :1207-1220.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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