BMP agonist 1

BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP) . BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1].

Product Specifications

UNSPSC

12352005

Target

GSK-3; TGF-β Receptor; β-catenin

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/bmp-agonist-1.html

Solubility

10 mM in DMSO

Smiles

OC1=CC2=C(C=C1)NC3=C2C(C(N4)=O)=C(C5=CC(OC)=C(C(OC)=C53)OC)C4=O

Molecular Formula

C21H16N2O6

Molecular Weight

392.36

References & Citations

[1]Riege D, et al. Identification of Maleimide-Fused Carbazoles as Novel Noncanonical Bone Morphogenetic Protein Synergizers. ACS Pharmacol Transl Sci. 2023 Jul 19;6 (8) :1207-1220.