Mz438

Mz438 is high-affinity and selective fluorescent CXCR2 ligand. Mz438 is a small-molecule-based fluorescent probe targeting the IABS of CXCR2[1].

Product Specifications

UNSPSC

12171500

Target

CXCR; Fluorescent Dye

Type

Dye Reagents

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/mz438.html

Solubility

10 mM in DMSO

Smiles

CC(C)([C@H](C1=CC=C(O1)C)NC2=C(C(C2=O)=O)NC(C=CC=C3C(NCC(N=N4)=CN4CCOCCOCCOCCNC(C5=CC=C(C([O-])=O)C(C(C(C=C6)=C(O7)C=C6N(C)C)=C8C7=C/C(C=C8)=[N+](C)/C)=C5)=O)=O)=C3O)C

Molecular Formula

C57H63N9O12

Molecular Weight

1066.16

References & Citations

[1]Huber ME, et, al. Fluorescent Ligands Enable Target Engagement Studies for the Intracellular Allosteric Binding Site of the Chemokine Receptor CXCR2. J Med Chem. 2023 Jul 27;66 (14) :9916-9933.