HDAC-IN-61

HDAC-IN-61 (compound 12k) is a potent and orally active HDAC inhibitor. HDAC-IN-61 has anticancer active with an IC50 value of 30 nM for Bel-7402 cell. HDAC-IN-61 can be used in research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-61.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N1CCC(C2=CC=C(C=C2O3)OC)=C3C1)CC4=CC=CC=C4)NC5=CC=C(C=C5)C(NO)=O

Molecular Formula

C28H27N3O5

Molecular Weight

485.53

References & Citations

[1]Lai Z, et, al. Discovery of Novel 1,2,3,4-Tetrahydrobenzofuro[2,3-c]pyridine Histone Deacetylase Inhibitors for Efficient Treatment of Hepatocellular Carcinoma. J Med Chem. 2023 Aug 10;66 (15) :10791-10807.