Topoisomerase II inhibitor 16
Selected Variant
HY-155693-01
Size: 1 mg
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research[1].
Product Specifications
CAS Number
2403729-27-9
UNSPSC
12352005
Target
Parasite; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-16.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=C(C2=CC=C(CN(C(CN3C=NC(C#N)=N3)=O)C4)C4=C2)C=C(F)C=N1
Molecular Formula
C19H12F4N6O
Molecular Weight
416.33
References & Citations
[1]Srinivasa P S Rao, et al. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023 Jun 30;380 (6652) :1349-1356.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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