SWS1
SWS1 is a d- (+) -biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%) [1].
Product Specifications
CAS Number
2922115-32-8
UNSPSC
12352005
Target
Monoamine Oxidase; PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sws1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1N(CCCC1)CC2=C(C=C(C(Cl)=C2)OCC3=C(C(C4=CC=CC=C4)=CC=C3)C)OCC5=CC(C#N)=CC=C5)NCCNC(CCCC[C@H]6[C@]7([H])[C@](NC(N7)=O)([H])CS6)=O
Molecular Formula
C47H53ClN6O5S
Molecular Weight
849.48
References & Citations
[1]Ding Z, et al. Discovery of Novel d- (+) -Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66 (15) :10364-10380..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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