SARS-CoV-2 nsp14-IN-4
SARS-CoV-2 nsp14-IN-4 (Compound 12q) is an inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50=19 nM) . SARS-CoV-2 nsp14-IN-4 is non-cytotoxic and cell-permeable. SARS-CoV-2 nsp14-IN-4 is used in COVID-19 research[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-nsp14-in-4.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=C(C#CC3=CC4=CC=CC=C4N=C3)C(C2=NC=N5)=C5N)O[C@@H]1CN(C)S(C6=CC=C(OC)C(C#N)=C6)(=O)=O
Molecular Formula
C31H27N7O6S
Molecular Weight
625.65
References & Citations
[1]Štefek M, et al. Rational Design of Highly Potent SARS-CoV-2 nsp14 Methyltransferase Inhibitors. ACS Omega. 2023 Jul 21;8 (30) :27410-27418.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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