eIF4E-IN-5
Product Specifications
UNSPSC Description
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation[1].
Target Antigen
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eif4e-in-5.html
Solubility
10 mM in DMSO
Smiles
NC1=NC2=C(C(N1)=O)[N+](CC3=CC4=C(N3)C=CC(Cl)=C4)=CN2C/C=C\CP(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O.[Cl-]
Molecular Weight
713.55
References & Citations
[1]Cárdenas EL, et al. Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer. J Med Chem. 2023 Aug 10;66(15):10734-10745.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155676/eIF4E-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155676/
Clinical Information
No Development Reported
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