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HMG-CoA Reductase-IN-1

HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC50 and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia[1].

Product Specifications

UNSPSC

12352005

Target

HMG-CoA Reductase (HMGCR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hmg-coa-reductase-in-1.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C(C=C1)NC(C2=C(/C=C/[C@H](C[C@@H](O)CC(O)=O)O)C(C(C)C)=NC(C3=CC=C(C=C3)O)=N2)=O

Molecular Formula

C27H29N3O7

Molecular Weight

507.54

References & Citations

[1]Samizo S, et al. Predictive Modeling of HMG-CoA Reductase Inhibitory Activity and Design of New HMG-CoA Reductase Inhibitors. ACS Omega. 2023 Jul 18;8 (30) :27247-27255.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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