PROTAC TG2 degrader-1
PROTAC TG2 degrader-1 (compound 11) is a von Hippel-Lindau (VHL) -based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. PROTAC TG2 degrader-1 reduces TG2 in ovarian cancer cells in a proteasome-dependent manner[1].
Product Specifications
CAS Number
3033465-55-0
UNSPSC
12352005
Target
Glutaminase; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-tg2-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCOCCOCCN(C2=NC(NC3=CC=C(NC(CC4=CC=CC=C4)=O)C=C3)=NC(C)=C2)C)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
Molecular Formula
C55H73N9O10S
Molecular Weight
1052.29
References & Citations
[1]Andres Valdivia, et al. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2) . J Med Chem. 2023 Jul 27;66 (14) :9445-9465.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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