PROTAC TG2 degrader-1

PROTAC TG2 degrader-1 (compound 11) is a von Hippel-Lindau (VHL) -based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. PROTAC TG2 degrader-1 reduces TG2 in ovarian cancer cells in a proteasome-dependent manner[1].

Product Specifications

CAS Number

[3033465-55-0]

UNSPSC

12352005

Target

Glutaminase; PROTACs

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-tg2-degrader-1.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCOCCOCCOCCOCCOCCN(C2=NC(NC3=CC=C(NC(CC4=CC=CC=C4)=O)C=C3)=NC(C)=C2)C)=O)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Molecular Formula

C55H73N9O10S

Molecular Weight

1052.29

References & Citations

[1]Andres Valdivia, et al. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2) . J Med Chem. 2023 Jul 27;66 (14) :9445-9465.