PD25

PD25 is an AChE and BuChE inhibitor (hAChE IC50: 1.58 μM; eeAChE IC50: 1.63 μM; eqBuChE IC50: 2.39 μM) . PD25 also has antioxidant activity, and inhibits DPPH (IC50: 29.55 μM) . PD25 can be used for research of Alzheimer’s disease[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd25.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(C(/C=C/C2=CC=CC=C2)=O)CC1)/C=C/C=C/C3=CC=C(OCO4)C4=C3

Molecular Formula

C25H24N2O4

Molecular Weight

416.47

References & Citations

[1]Bhanukiran K, et al. Discovery of Multitarget-Directed Ligands from Piperidine Alkaloid Piperine as a Cap Group for the Management of Alzheimer's Disease. ACS Chem Neurosci. 2023 Aug 2;14 (15) :2743-2760.