KSK68
KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain[1].
Product Specifications
CAS Number
2566715-91-9
UNSPSC
12352005
Target
Histamine Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ksk68.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CC1)C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2
Molecular Formula
C23H28N2O2
Molecular Weight
364.48
References & Citations
[1]Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66 (14) :9658-9683.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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