M867

M867 is a selective and reversible inhibitor of caspase-3 with an IC50 of 1.4 nM and Ki of 0.7 nM. M867 has anti apoptotic activity[1].

Product Specifications

CAS Number

[680999-39-7]

UNSPSC

12352005

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m867.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C=C(N=C1NCC2=NON=C2C)C(C)(C)C)[C@H](C(N[C@H](C(CN(CCCCC)C)=O)CC(O)=O)=O)CC

Molecular Formula

C27H43N7O6

Molecular Weight

561.67

References & Citations

[1]Han Y, et.al. Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15 (4) :1173-80.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Caspase 3

Curated Selection

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