M826
Product Specifications
UNSPSC Description
M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research[1].
Target Antigen
Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/m826.html
Purity
99.75
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CC(NC([C@@H](N1C(C(NCC2=NON=C2C)=NC(C(C)(C)C)=C1)=O)CC)=O)C(CN(C)CCCCCC)=O
Molecular Weight
575.70
References & Citations
[1]Han BH, et al. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of cell death after neonatal hypoxic-ischemic brain injury. J Biol Chem. 2002 Aug 16;277(33):30128-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155612/M826-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155612/M826-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
321437-16-5
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