Cathepsin C-IN-6
Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase, exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g., chronic obstructive pulmonary disease) [1].
Product Specifications
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cathepsin-c-in-6.html
Solubility
10 mM in DMSO
Smiles
CCCCNNC([C@@H]1O[C@H]1C(N[C@H](C(NCCC2=CNC3=C2C=CC=C3)=O)CCCC)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C24H35N5O4.xC2HF3O2
References & Citations
[1]Tromsdorf N, et al. E‐64c‐hydrazide based cathepsin C inhibitors: Optimizing the interactions with the S1’‐S2’area[J]. ChemMedChem, 2023: e202300218..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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