LT-540-717
LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V) . LT-540-717 has potential to be an anti-AML agent[1].
Product Specifications
CAS Number
2143089-35-2
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lt-540-717.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(N2CCNCC2)C=C1)C3=NNC=C3NC4=NC=NC(OC5=CC=CC=C5)=C4
Molecular Formula
C24H24N8O2
Molecular Weight
456.50
References & Citations
[1]Zhi Y, et al. Rational design of 4- ((6-phenoxypyrimidin-4-yl) amino) -N- (4- (piperazin-1-yl) phenyl) -1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor. Eur J Med Chem. 2023 Aug 5;256:115448.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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