Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MAO A/HSP90-IN-2

MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].

Product Specifications

CAS Number

2927489-99-2

UNSPSC

12352005

Target

HSP; Monoamine Oxidase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mao-a-hsp90-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C=C(C(C(C)C)=C1)O)O)N(C2=CC(Cl)=C(C=C2)OCCCN(CC#C)C)CC

Molecular Formula

C25H31ClN2O4

Molecular Weight

458.98

References & Citations

[1]1、Hui-Ju Tseng, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. European Journal of Medicinal Chemistry. Volume 256, 5 August 2023, 115459.|[2]Hui-Ju Tseng, et al. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. European Journal of Medicinal Chemistry. Volume 256, 5 August 2023, 115459.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

HSP90; MAO-A

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Ethyl 4-[[6-(4-Carbamimidoylphenoxy)hexyl]oxy]benzimidoate dihydrochloride
TRC-E901035-5MG 5 mg

Ethyl 4-[[6-(4-Carbamimidoylphenoxy)hexyl]oxy]benzimidoate dihydrochloride

Sign In for Pricing
View Details
CD11c (Dendritic Cell Marker) (ITGAX/1284), CF647 conjugate, 0.1mg/mL
BNC471284-500 1x 500 µL

CD11c (Dendritic Cell Marker) (ITGAX/1284), CF647 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
1,4-Dichlorobutane-d8
TRC-D436009-50MG 50 mg

1,4-Dichlorobutane-d8

Sign In for Pricing
View Details
Calponin-1 (CALP), CF594 conjugate, 0.1mg/mL
BNC940831-500 1x 500 µL

Calponin-1 (CALP), CF594 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Mouse Anti-Mouse PD-L1 (10F.9G2) Recombinant Antibody (LALAPG)
ICH1183LALAPG-20mg 20 mg

Mouse Anti-Mouse PD-L1 (10F.9G2) Recombinant Antibody (LALAPG)

Sign In for Pricing
View Details
Mouse PYY (Peptide YY) ELISA Kit
E-EL-M2375-01 24 Tests

Mouse PYY (Peptide YY) ELISA Kit

Sign In for Pricing
View Details