MAO A/HSP90-IN-2
MAO A/HSP90-IN-2 (compound 4-C) is a dual inhibitor of HSP90and MAO A with the IC50 values of 0.016 and 4.58 μM, respectively. MAO A/HSP90-IN-2 increases HSP70 expression and reduces HER2 and phospho-Akt expression, and decreases IFN-γ induced PD-L1 expression in GL26 cells. MAO A/HSP90-IN-2 inhibits the growth of Temozolomide -sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung and other cancers, and has potential to inhibit tumor immune escape[1].
Product Specifications
CAS Number
2927489-99-2
UNSPSC
12352005
Target
HSP; Monoamine Oxidase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mao-a-hsp90-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(C(C(C)C)=C1)O)O)N(C2=CC(Cl)=C(C=C2)OCCCN(CC#C)C)CC
Molecular Formula
C25H31ClN2O4
Molecular Weight
458.98
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
HSP90; MAO-A
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
MMP9 (rMMP9/1769), CF640R conjugate, 0.1mg/mL
