Nrf2 activator-8
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM) . Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS) -induced neuroinflammation[1].
Product Specifications
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-8.html
Solubility
10 mM in DMSO
Smiles
O=S(/C=C/C1=NC=CC=C1Cl)(C2=NC=CC=C2OC)=O
Molecular Formula
C13H11ClN2O3S
Molecular Weight
310.76
References & Citations
[1]Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal FGFR5/FGFRL1 Antibody (019) [Alexa Fluor 700]](https://cdn.genprice.uk/genprice/uk/genprice4.webp)
NBP2-90467AF700 0.1 mL
Rabbit Monoclonal FGFR5/FGFRL1 Antibody (019) [Alexa Fluor 700]
Ask
View Details 
MBS2032870-01 0.1 mL
Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) Polyclonal Antibody
Ask
View Details MBS2032870-02 0.2 mL
Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) Polyclonal Antibody
Ask
View Details 
MBS2032870-03 0.5 mL
Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) Polyclonal Antibody
Ask
View Details MBS2032870-04 1 mL
Inhibitor Of Kappa-Light Polypeptide Gene Enhancer In B-Cells Kinase Beta (IkBKb) Polyclonal Antibody
Ask
View Details