Nrf2 activator-8
Product Specifications
UNSPSC Description
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM). Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS)-induced neuroinflammation[1].
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-8.html
Solubility
10 mM in DMSO
Smiles
O=S(/C=C/C1=NC=CC=C1Cl)(C2=NC=CC=C2OC)=O
Molecular Weight
310.76
References & Citations
[1]Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155572/Nrf2-activator-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155572/
Clinical Information
No Development Reported
Curated Selection
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