Anti-inflammatory agent 46
Anti-inflammatory agent 46 (compound 7h) is an anti-inflammatory agent with nitric oxide (NO) inhibitory effect. Anti-inflammatory agent 46 binds to iNOS with low energies, inhibits swelling in mice (at dose of 10 mg/kg) [1].
Product Specifications
CAS Number
[2925586-96-3]
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-46.html
Solubility
10 mM in DMSO
Smiles
O=S(N1N2[C@@](C3=CC=CC=C3C=C2)([H])[C@@H](C4=CC=C(C=C4)F)C1=O)(C5=CC=C(C=C5)C)=O
Molecular Formula
C24H19FN2O3S
Molecular Weight
434.48
References & Citations
[1]Akhtar M, et al. Anti-inflammatory efficacy and relevant SAR investigations of novel chiral pyrazolo isoquinoline derivatives: Design, synthesis, in-vitro, in-vivo, and computational studies targeting iNOS. Eur J Med Chem. 2023 Aug 5;256:115412.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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