Anti-inflammatory agent 46

Anti-inflammatory agent 46 (compound 7h) is an anti-inflammatory agent with nitric oxide (NO) inhibitory effect. Anti-inflammatory agent 46 binds to iNOS with low energies, inhibits swelling in mice (at dose of 10 mg/kg) [1].

Product Specifications

CAS Number

[2925586-96-3]

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-46.html

Solubility

10 mM in DMSO

Smiles

O=S(N1N2[C@@](C3=CC=CC=C3C=C2)([H])[C@@H](C4=CC=C(C=C4)F)C1=O)(C5=CC=C(C=C5)C)=O

Molecular Formula

C24H19FN2O3S

Molecular Weight

434.48

References & Citations

[1]Akhtar M, et al. Anti-inflammatory efficacy and relevant SAR investigations of novel chiral pyrazolo isoquinoline derivatives: Design, synthesis, in-vitro, in-vivo, and computational studies targeting iNOS. Eur J Med Chem. 2023 Aug 5;256:115412.