CSF1R-IN-17

CSF1R-IN-17 (compound 9) is a potent and selective CSF1R antagonist, with an IC50 of 0.2 nM. CSF1R-IN-17 can inhibit osteoclast differentiation[1].

Product Specifications

UNSPSC

12352005

Target

C-Fms

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/csf1r-in-17.html

Solubility

10 mM in DMSO

Smiles

OCCC1=CC=C(C2=NC3=C(N(C)CC4CCOCC4)N=CN=C3N2)C=C1

Molecular Formula

C20H25N5O2

Molecular Weight

367.44

References & Citations

[1]Aarhus TI, et, al. A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation. Eur J Med Chem. 2023 Jul 5;255:115344.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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