RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod -induced psoriasis in mice[1].
Product Specifications
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-31.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(C2=NC(NC3=CC=C(S(=O)(C)=O)C=C3)=NC(OC4=C(Cl)C=CC=C4Cl)=N2)C=C1)(F)F
Molecular Formula
C23H15Cl2F3N4O3S
Molecular Weight
555.36
References & Citations
[1]Lu L, et, al. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists. Eur J Med Chem. 2023 Aug 5;256:115424.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY426298 100 µg
C16orf92 (NM_001109659) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC882176-100 1x 100 µL
MMP9 (rMMP9/1769), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
