RORγt inverse agonist 31
RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod -induced psoriasis in mice[1].
Product Specifications
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rorγt-inverse-agonist-31.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=C(C2=NC(NC3=CC=C(S(=O)(C)=O)C=C3)=NC(OC4=C(Cl)C=CC=C4Cl)=N2)C=C1)(F)F
Molecular Formula
C23H15Cl2F3N4O3S
Molecular Weight
555.36
References & Citations
[1]Lu L, et, al. Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists. Eur J Med Chem. 2023 Aug 5;256:115424.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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