SARS-CoV-2 3CLpro-IN-14
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC50 = 0.18 μM) and low cytotoxicity (CC50 > 50 μM) in Vero E6 cells[1].
Product Specifications
CAS Number
2945139-50-2
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sars-cov-2-3clpro-in-14.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)S(=O)(N[C@H](C(N1[C@@H](C2)CC[C@@H]2[C@H]1C(N[C@H](C(C3=NC4=CC=CC=C4S3)=O)C[C@@H]5CCNC5=O)=O)=O)C6(C7)C[C@@H](C8)C[C@H]7C[C@@H]8C6)=O
Molecular Formula
C34H40F3N5O6S2
Molecular Weight
735.84
References & Citations
[1]Yang H, et al. Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2. Eur J Med Chem. 2023 Sep 5;257:115512.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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