Mibefradil (dihydrochloride hydrate)

Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels[1].

Product Specifications

CAS Number

[1049728-52-0]

Product Name Alternative

Ro 40-5967 (dihydrochloride hydrate)

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/mibefradil-dihydrochloride-hydrate.html

Solubility

10 mM in DMSO

Smiles

[H]O[H].O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC.[H]Cl.[H]Cl

Molecular Formula

C29H42Cl2FN3O4

Molecular Weight

586.57

References & Citations

[1]Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA. Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther. 2000 Oct;295 (1) :302-8.|[2]Mehrke G, et al. The Ca (++) -channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1483-8.|[3]Brain KL, et al. The sources and sequestration of Ca (2+) contributing to neuroeffector Ca (2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553 (Pt 2) :627-35.