YF704
YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM) . YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells[1].
Product Specifications
CAS Number
2956716-97-3
UNSPSC
12352005
Target
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yf704.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4
Molecular Formula
C17H20Cl2N4OS2
Molecular Weight
431.40
References & Citations
[1]Liu WS, et al. Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer. Eur J Med Chem. 2023 Oct 5;258:115585.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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