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PEX5-PEX14 PPI-IN-2

PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC50 values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection[1].

Product Specifications

UNSPSC

12352005

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pex5-pex14-ppi-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)[C@@H](N1C[C@H](CC2=CNC3=C2C=CC=C3)NC(C1)=O)CC4=CNC5=C4C=CC=C5

Molecular Formula

C25H26N4O3

Molecular Weight

430.50

References & Citations

[1]Marciniak M, et al. Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. Eur J Med Chem. 2023 Oct 5;258:115587.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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