PEX5-PEX14 PPI-IN-1
Product Specifications
UNSPSC Description
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM)[1].
Target Antigen
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pex5-pex14-ppi-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)[C@@H](N1C([C@H](CC2=CNC3=C2C=CC=C3)NCCC1)=O)CC4=CNC5=C4C=CC=C5
Molecular Weight
444.53
References & Citations
[1]Marciniak M, et al. Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. Eur J Med Chem. 2023 Oct 5;258:115587.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155530/PEX5-PEX14-PPI-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155530/
Clinical Information
No Development Reported
Curated Selection
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