PEX5-PEX14 PPI-IN-1

PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM) [1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pex5-pex14-ppi-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(OC)[C@@H](N1C([C@H](CC2=CNC3=C2C=CC=C3)NCCC1)=O)CC4=CNC5=C4C=CC=C5

Molecular Formula

C26H28N4O3

Molecular Weight

444.53

References & Citations

[1]Marciniak M, et al. Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template. Eur J Med Chem. 2023 Oct 5;258:115587.