DprE1-IN-5

DprE1-IN-5 (Compound 10) is a DprE1 inhibitor. DprE1-IN-5 has anti-TB activity against Mtb H37Rv strain (MIC: 4 μM) . DprE1-IN-5 also has antimycobacterial activity against drug-resistant strains. DprE1-IN-5 has high microsomal stability[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dpre1-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(N2CCOCC2)=NC3=C1N(CC4=CC=C5C=CC=CC5=C4)C=N3

Molecular Formula

C20H19N5O2

Molecular Weight

361.40

References & Citations

[1]Finger V, et al. 2,6-Disubstituted 7- (naphthalen-2-ylmethyl) -7H-purines as a new class of potent antitubercular agents inhibiting DprE1. Eur J Med Chem. 2023 Oct 5;258:115611.