4'-Hydroxy diclofenac-13C6

4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac[1]. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9) . 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[2][3].

Product Specifications

CAS Number

[1189656-64-1]

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

Drug Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-hydroxy-diclofenac-13c6.html

Purity

0.993

Solubility

10 mM in DMSO

Smiles

ClC(C=C(C=C1Cl)O)=C1N[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)CC(O)=O

Molecular Formula

C8 13C6H11Cl2NO3

Molecular Weight

318.10

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56 (1) :65-8.|[3]Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar43 (3) :309-16.