NAMPT degrader-3
NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation[1].
Product Specifications
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-degrader-3-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(CCCCCCCNC(C1=CC=C(C(N2CCC(CC2)CCCCNC(/C=C/C3=CC=CN=C3)=O)=O)C=C1)=O)=O)C(C)(C)C)N4C[C@@H](C[C@H]4C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)O
Molecular Formula
C56H74N8O7S
Molecular Weight
1003.30
References & Citations
[1]Zhang P, et al. Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead. Bioorg Med Chem Lett. 2023 Jun 25;92:129393.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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