Metallo-β-lactamase-IN-11
Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM) . Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/metallo-β-lactamase-in-11.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(/N=C/C2=CC=C(O)C=C2)N(CC3=CC=CC=C3)C(C4=CC=CC=C4)=C1C5=CC=CC=C5
Molecular Formula
C31H23N3O
Molecular Weight
453.53
References & Citations
[1]Kurz JL, et al. Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance. Bioorg Med Chem Lett. 2023 Jun 25;92:129387.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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