AKR1C3-IN-10
AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC50=51 nM) . AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model[1].
Product Specifications
CAS Number
3028287-43-3
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akr1c3-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C(C=C2)=CN3C2=NC=N3)=CC(/C=C/C(O)=O)=C1)NCC4=CC=C(C=C4)C
Molecular Formula
C24H20N4O3
Molecular Weight
412.44
References & Citations
[1]Maddeboina K, et al. Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model. J Med Chem. 2023 Jul 27;66 (14) :9894-9915.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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