JTE-151

JTE-151 is a RORγ inhibitor, which can suppress overactive immune response through inhibition of RORγ related to the activation of Th17 cells, making JTE-151 possible to be used in autoimmune disease research[1].

Product Specifications

CAS Number

[1404380-58-0]

UNSPSC

12352005

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jte-151.html

Purity

99.34

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=CC(C)=CC=C1NC(C[C@H](CCC(O)=O)C2=NOC([C@@H]3C[C@H](CC(C)(C)C)C3)=C2C4CC4)=O

Molecular Formula

C28H37ClN2O4

Molecular Weight

501.06

References & Citations

[1]Hiromu Takiguchi, et al. Practical Synthesis of Chiral 3- (Hydroxyiminomethyl) adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution