PSB-22034
PSB-22034 (compound 30d) is a selective agonist of MRGPRX4 with EC50s of 11.2 nM and 30.0 nM in Ca2+ and β-arrestin experiments, respectively[1].
Product Specifications
CAS Number
[2768131-22-0]
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mrgprx4-agonist-1.html
Purity
99.0000
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N(C(N1CC#C)=O)CCCCP(O)(O)=O)N=C(N2)CCC3=CC(OC)=CC=C3
Molecular Formula
C21H25N4O6P
Molecular Weight
460.42
References & Citations
[1]Marx D et al. Discovery of Potent Agonists for the Predominant Variant of the Orphan MAS-Related G Protein-Coupled Receptor X4 (MRGPRX4) . J Med Chem. 2023 Nov 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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