Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM) . Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](NC(C2=CC=CC=C2CN3CCO[C@@H](C)C3)=O)N=C(C4=CC=CC=C4)C5=CC=NC=C5N1
Molecular Formula
C27H27N5O3
Molecular Weight
469.53
References & Citations
[1]Boerth J A et al. Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1498725-01 0.05 mg
Rabbit anti-human Glycosyltransferase 8 domain-containing protein 2 polyclonal Antibody, Biotin conjugated
Sign In for Pricing
View Details MBS1498725-02 0.1 mg
Rabbit anti-human Glycosyltransferase 8 domain-containing protein 2 polyclonal Antibody, Biotin conjugated
Sign In for Pricing
View Details MBS1498725-03 5x 0.1 mg
Rabbit anti-human Glycosyltransferase 8 domain-containing protein 2 polyclonal Antibody, Biotin conjugated
Sign In for Pricing
View Details