Cbl-b-IN-15

Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM) . Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM[1].

Product Specifications

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbl-b-in-15.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@H](NC(C2=CC=CC=C2CN3CCO[C@@H](C)C3)=O)N=C(C4=CC=CC=C4)C5=CC=NC=C5N1

Molecular Formula

C27H27N5O3

Molecular Weight

469.53

References & Citations

[1]Boerth J A et al. Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity[J]. ACS Medicinal Chemistry Letters, 2023.