Cbl-b-IN-15
Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM) . Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](NC(C2=CC=CC=C2CN3CCO[C@@H](C)C3)=O)N=C(C4=CC=CC=C4)C5=CC=NC=C5N1
Molecular Formula
C27H27N5O3
Molecular Weight
469.53
References & Citations
[1]Boerth J A et al. Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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