Me4Phen
Product Specifications
UNSPSC Description
Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin (HY-17394) resistance in a variety of cancer cells[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/me4phen.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C)C(C=CC2=C3[N]([Re]45(OCCO5)(Cl)=O)=CC(C)=C2C)=C3[N]4=C1
Molecular Weight
534.02
References & Citations
[1]Das S et al. Necrosis-Inducing High-Valent Oxo-Rhenium(V) Complexes with Potent Antitumor Activity: Synthesis, Aquation Chemistry, Cisplatin Cross-Resistance Profile, and Mechanism of Action. Inorg Chem. 2023 Nov 16.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155474/Me4Phen-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155474/
Clinical Information
No Development Reported
Curated Selection
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