Me4Phen
Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin (HY-17394) resistance in a variety of cancer cells[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/me4phen.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C)C(C=CC2=C3[N]([Re]45(OCCO5)(Cl)=O)=CC(C)=C2C)=C3[N]4=C1
Molecular Formula
C18H20ClN2O3Re
Molecular Weight
534.02
References & Citations
[1]Das S et al. Necrosis-Inducing High-Valent Oxo-Rhenium (V) Complexes with Potent Antitumor Activity: Synthesis, Aquation Chemistry, Cisplatin Cross-Resistance Profile, and Mechanism of Action. Inorg Chem. 2023 Nov 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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