VEGFR-2/AURKA-IN-1

VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229) . VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential[1].

Product Specifications

UNSPSC

12352005

Target

Aurora Kinase; VEGFR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vegfr-2-aurka-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)COC1=C(C(NN2C(C3=CC=C(Cl)C=C3)SCC2=O)=O)C=C(OCC(F)(F)F)C=C1

Molecular Formula

C20H15ClF6N2O4S

Molecular Weight

528.85

References & Citations

[1]D Shankara S et al. Vetting of New 2, 5-Bis (2, 2, 2-trifluoroethoxy) Phenyl-Linked 1, 3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies[J]. ACS Omega, 2023.