VEGFR-2/AURKA-IN-1
Product Specifications
UNSPSC Description
VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential[1].
Target Antigen
Aurora Kinase; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-aurka-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)COC1=C(C(NN2C(C3=CC=C(Cl)C=C3)SCC2=O)=O)C=C(OCC(F)(F)F)C=C1
Molecular Weight
528.85
References & Citations
[1]D Shankara S et al. Vetting of New 2, 5-Bis (2, 2, 2-trifluoroethoxy) Phenyl-Linked 1, 3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies[J]. ACS Omega, 2023.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155464/VEGFR-2-AURKA-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155464/
Clinical Information
No Development Reported
Curated Selection
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