CDK2-IN-20

CDK2-IN-20 (compound 3b) is an inhibitor of CDK2. CDK2-IN-20 has cytotoxicity on tumor cells presenting an IC50 range of 5.52-17.09 µM. CDK2-IN-20 arrests the MCF-7 cell cycle at the S phase and induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-in-20.html

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=CC=C1C(S2)C(C#N)=C(N)N3C=NC4=C3C2=NC=N4

Molecular Formula

C15H9ClN6S

Molecular Weight

340.79

References & Citations

[1]Ebtehal M Husseiny, et al. Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations. Bioorg Chem. 2023