PFI-6

PFI-6 is a non-cytotoxic and selective MLLT1/3 probe targeting the YEATS domain of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) . PFI-6 shows IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 can serve as a molecular tool to explore the role of MLLT1/3 in various diseases and related genome validation studies[1].

Product Specifications

CAS Number

[2675452-91-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pfi-6.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(N(C)C)C1=CC=C(C2=CC(C(N[C@H]3C(C=CC=C4)=C4CC3)=O)=NO2)C=C1O

Molecular Formula

C22H21N3O4

Molecular Weight

391.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Raux B, et al. Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3. Bioorg Med Chem Lett. 2023 Nov 7:129546.