Caspase-3 activator 3

Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC50 values of 42.89 and 33.61 μM, respectively[1].

Product Specifications

CAS Number

[2999724-54-6]

UNSPSC

12352005

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/caspase-3-activator-3.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(C2=CC=C(C3CC(C4=CSC=C4)=NN3C5=CC=CC(Br)=C5)C=C2)CC1

Molecular Formula

C24H25BrN4S

Molecular Weight

481.45

References & Citations

[1]Mehlika Dilek Altıntop, et al. Design, Synthesis, and Evaluation of a New Series of 2-Pyrazolines as Potential Antileukemic Agents. ACS Omega 2023.