Caspase-3 activator 3
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC50 values of 42.89 and 33.61 μM, respectively[1].
Product Specifications
CAS Number
[2999724-54-6]
UNSPSC
12352005
Target
Apoptosis; Caspase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caspase-3-activator-3.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C2=CC=C(C3CC(C4=CSC=C4)=NN3C5=CC=CC(Br)=C5)C=C2)CC1
Molecular Formula
C24H25BrN4S
Molecular Weight
481.45
References & Citations
[1]Mehlika Dilek Altıntop, et al. Design, Synthesis, and Evaluation of a New Series of 2-Pyrazolines as Potential Antileukemic Agents. ACS Omega 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3
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