APS3

APS3 is a GABA and nACh receptors inhibitor, with a LC50 of 7.2423 μg/mL against Plutella xylostella[1].

Product Specifications

CAS Number

[1225373-70-5]

UNSPSC

12352005

Target

GABA Receptor; nAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/aps3.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)C1=CC(Cl)=C(N2N=C(C#N)C(S(C(F)(F)F)=O)=C2NS(C3=CC=C([N+]([O-])=O)C=C3)(=O)=O)C(Cl)=C1

Molecular Formula

C18H7Cl2F6N5O5S2

Molecular Weight

622.31

References & Citations

[1]Yueyue Xu, et al. Design and One-Pot Ultrasound Synthesis of Inorganic Base-Promoted Fluorescent Ligand-Gated Ion Channel Fused Arylpyrazole Sulfonamide Skeletons to Enhance Phloem Mobility and Insecticidal Activity as GABA and nACh Receptors Inhibitors. J Agric Food Chem. 2023 Nov 1;71 (43) :16331-16351.