MTOR inhibitor-14

MTOR inhibitor-14 (compound 14c) is a potent mTOR inhibitor. mTOR inhibitor-14 also shows minimal CYP2C8 inhibition. mTOR inhibitor-14 can inhibit tumor growth[1].

Product Specifications

UNSPSC

12352005

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtor-inhibitor-14.html

Solubility

10 mM in DMSO

Smiles

O[C@H](CC1)CC[C@@H]1N(C2=CN=C(C3=CC=CC4=C3C=CN4)N=C2N5[C@@]6(C)COCC5)C6=O

Molecular Formula

C24H27N5O3

Molecular Weight

433.50

References & Citations

[1]Sean T. Murphy, et al. Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free–Wilson Analysis for Improved In Vivo Efficacy. ACS Med. Chem. Lett. 2023.