BChE-IN-20
BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.
Product Specifications
CAS Number
1428439-79-5
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-in-20.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)/C(C1)=C/N(C(C)C)CCC2=C1C(NCCCN(CC)CC)=NC(C3=CC=CC=C3)=N2
Molecular Formula
C27H39N5O2
Molecular Weight
465.63
References & Citations
[1]Modesto de Candia, et al. In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase. Chem Biol Interact. 2023 Oct 13:386:110741.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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