HAChE-IN-6
HAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research[1].
Product Specifications
CAS Number
[3007667-17-3]
UNSPSC
12352005
Target
Cholinesterase (ChE) ; GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-6.html
Solubility
10 mM in DMSO
Smiles
NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
Molecular Formula
C20H17BrN4O2
Molecular Weight
425.28
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155366/hAChE-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155366/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; GSK-3β
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