hAChE-IN-6
Product Specifications
UNSPSC Description
hAChE-IN-6 (compound 51) is a brain penetrant AChE inhibitor with an IC50 of 0.16 μM. hAChE-IN-6 also inhibits hBuChE and GSK3β with IC50 values of 0.69 μM and 0.26 μM, respectively. hAChE-IN-6 inhibits tau protein and Aβ1-42 self-aggregation, and can be used for Alzheimer's disease (AD) research[1].
Target Antigen
Cholinesterase (ChE); GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hache-in-6.html
Solubility
10 mM in DMSO
Smiles
NC1=NNC2=NC(C3=CC=C(Br)C=C3)=CC(C4=CC(OC)=C(OC)C=C4)=C21
Molecular Weight
425.28
References & Citations
[1]Omnia M Waly, et al. Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids. Eur J Med Chem. 2023 Oct 20:262:115880.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155366/hAChE-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155366/
Clinical Information
No Development Reported
CAS Number
3007667-17-3
Curated Selection
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